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Diphenhydramine (hydrochloride)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008
111581.1 Product Code:
Section 1. Identification of the Substance/Mixture and of the Company/Undertaking
Diphenhydramine (hydrochloride) Product Name:
Cayman Chemical CompanyCompany Name:
1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
CHEMTREC Within USA and Canada:Emergency Contact:+1 (800)424-9300
CHEMTREC Outside USA and Canada: +1 (703)527-3887
Cayman Chemical CompanyInformation:+1 (734)971-3335
For research use only, not for human or veterinary use.Relevant identified uses:
www.caymanchem.comWeb site address:
2-(diphenylmethoxy)-N,N-dimethyl-ethanamine, monohydrochloride; DPH; Synonyms:
1.3 Details of the Supplier of the Safety Data Sheet:
1.2 Relevant identified uses of the substance or mixture and uses advised against:
1.4 Emergency telephone number:
Section 2. Hazards Identification
Acute Toxicity: Oral, Category 3
2.1 Classification of the Substance or Mixture:
2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:
2.1.2 Classification according to Directive 1999/45/EC:
Xn: Harmful
N: Dangerous for the environment
Risk Phrases: R22, R43, R50/53
For full text of R- phrases: see SECTION 15.
H301: Toxic if swallowed.
GHS Hazard Phrases:
2.2 Label Elements:
2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:
DangerGHS Signal Word:
P264: Wash {hands} thoroughly after handling.
GHS Precaution Phrases:
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth.
GHS Response Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.
GHS Storage and Disposal Phrases:
Xn N
2.2.2 Labeling according to Directive 1999/45/EC:
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Diphenhydramine (hydrochloride)
SAFETY DATA SHEET
2.3 Material may be irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation or skin absorption.
May cause eye, skin, or respiratory system irritation.
Toxic if swallowed.
To the best of our knowledge, the toxicological properties have not been thoroughly
investigated.
Adverse Human Health
Effects and Symptoms:
CAS # /
RTECS #
Hazardous Components (Chemical Name)/
REACH Registration No.
Section 3. Composition/Information on Ingredients
Concentration EC No./
EC Index No.
Risk Phrases/
GHS Classification
147-24-0
KR7000000
Diphenhydramine hydrochloride 100.0 %205-687-2
NA
Xn;N; R22-43-50/53
Acute Tox.(O) 3: H301
Section 4. First Aid Measures
Description of First Aid
Measures:
Hold eyelids apart and flush eyes with plenty of water for at least 20 minutes. Have eyes
examined and tested by medical personnel.
In Case of Eye
Contact:
Immediately wash skin with soap and plenty of water for at least 20 minutes. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before
reuse.
In Case of Skin
Contact:
Wash out mouth with water provided person is conscious. Never give anything by mouth
to an unconscious person. Get medical attention. Do NOT induce vomiting unless
directed to do so by medical personnel.
In Case of Ingestion:
Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained
personnel. Get immediate medical attention.
In Case of Inhalation:
4.1
5.1
5.2
Section 5. Fire Fighting Measures
Flash Pt:No data.
As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH
approved or equivalent), and full protective gear to prevent contact with skin and eyes.
Fire Fighting
Instructions:
Autoignition Pt:No data.
Explosive Limits:LEL: No data. UEL: No data.
Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.
Use water spray to cool fire-exposed containers.
Suitable Extinguishing
Media:
A solid water stream may be inefficient.Unsuitable
Extinguishing Media:
No data available.Flammable Properties
and Hazards:
5.3
6.3
6.1
6.2
Section 6. Accidental Release Measures
Contain spill and collect, as appropriate.
Transfer to a chemical waste container for disposal in accordance with local regulations.
Methods and Material
For Containment and
Cleaning Up:
Avoid raising and breathing dust, and provide adequate ventilation.
As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or
respirator, and appropriate personal protection (rubber boots, safety goggles, and heavy
rubber gloves).
Protective Precautions,
Protective Equipment
and Emergency
Procedures:
Take steps to avoid release into the environment, if safe to do so.Environmental
Precautions:
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Diphenhydramine (hydrochloride)
SAFETY DATA SHEET
7.1
7.2
Section 7. Handling and Storage
Avoid breathing dust/fume/gas/mist/vapours/spray.
Avoid prolonged or repeated exposure.
Precautions To Be
Taken in Handling:
Keep container tightly closed.
Store in accordance with information listed on the product insert.
Precautions To Be
Taken in Storing:
Section 8. Exposure Controls/Personal Protection
Britain EH40 France VLCAS # Partial Chemical Name Europe
8.1 Exposure Parameters:
No data. No data. 147-24-0 Diphenhydramine hydrochloride No data.
OSHA TWA ACGIH TWACAS # Partial Chemical Name Other Limits
No data. No data. 147-24-0 Diphenhydramine hydrochloride No data.
8.2.1
NIOSH approved respirator, as conditions warrant.Respiratory Equipment
(Specify Type):
Safety glassesEye Protection:
Compatible chemical-resistant glovesProtective Gloves:
Lab coatOther Protective
Clothing:
Use process enclosures, local exhaust ventilation, or other engineering controls to
control airborne levels below recommended exposure limits.
Engineering Controls
(Ventilation etc.):
Do not take internally.
Facilities storing or utilizing this material should be equipped with an eyewash and a
safety shower.
Wash thoroughly after handling.
Work/Hygienic/Mainten
ance Practices:
8.2 Exposure Controls:
8.2.2 Personal protection equipment:
Section 9. Physical and Chemical Properties
Physical States:[ ] Gas [ ] Liquid [ X ] Solid
Melting Point:No data.
Boiling Point:No data.
Flash Pt:No data.
Explosive Limits:LEL: No data. UEL: No data.
Vapor Pressure (vs. Air or
mm Hg):
No data.
Vapor Density (vs. Air = 1):No data.
Evaporation Rate:No data.
A crystalline solidAppearance and Odor:
9.1 Information on Basic Physical and Chemical Properties
Specific Gravity (Water = 1):No data.
Solubility in Water:No data.
~10 mg/ml in PBS (pH 7.2); ~30 mg/ml in EtOH; ~20 mg/ml in DMSO; ~10 mg/ml
in DMF;
Solubility Notes:
Autoignition Pt:No data.
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Diphenhydramine (hydrochloride)
SAFETY DATA SHEET
Percent Volatile:No data.
9.2 Other Information
Molecular Formula & Weight:C17H21NO • HCl 291.8
10.4
10.5
10.6
10.1
10.2
10.3
Section 10. Stability and Reactivity
No data available.Conditions To Avoid:
Unstable [ ] Stable [ X ]Stability:
No data available.Incompatibility -
Materials To Avoid:
No data available.Hazardous
Decomposition Or
Byproducts:
Will occur [ ] Will not occur [ X ]Polymerization:
Stable if stored in accordance with information listed on the product insert.Stability Note(s):
No data available.Reactivity:
11.1
Section 11. Toxicological Information
The toxicological effects of this product have not been thoroughly studied.
Diphenhydramine (hydrochloride) - Toxicity Data: Oral TDLO (human-child): 12.5 mg/kg;
Oral TDLO (man): 10.714 mg/kg; Oral TDLO (woman): 83 mg/kg; Administration onto
the skin TDLO (human-child): 60 mg/kg/6H (intermittent); Oral LD50 (rat): 500 mg/kg;
Oral LD50 (mouse): 64 mg/kg; Inhalation TCLO (rat): 12 mg/m3/4H;
Information on
Toxicological Effects:
Diphenhydramine (hydrochloride) - Investigated as a mutagen, reproductive effector, and
tumorigen.
Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented
here. See actual entry in RTECS for complete information.
Diphenhydramine (hydrochloride) RTECS Number: KR7000000
Chronic Toxicological
Effects:
NTP? No IARC Monographs? No OSHA Regulated? NoCarcinogenicity:
12.1 Avoid release into the environment.
Runoff from fire control or dilution water may cause pollution.
Toxicity:
Section 12. Ecological Information
13.1 Dispose in accordance with local, state, and federal regulations.Waste Disposal
Method:
Section 13. Disposal Considerations
Section 14. Transport Information
Not dangerous goods.DOT Proper Shipping Name:
DOT Hazard Class:
UN/NA Number:
14.1 LAND TRANSPORT (US DOT):
Not dangerous goods.ADR/RID Shipping Name:
14.1 LAND TRANSPORT (European ADR/RID):
UN Number:
Hazard Class:
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Diphenhydramine (hydrochloride)
SAFETY DATA SHEET
Not dangerous goods.ICAO/IATA Shipping Name:
14.3 AIR TRANSPORT (ICAO/IATA):
Transport in accordance with local, state, and federal regulations.Additional Transport
Information:
CAS # Hazardous Components (Chemical Name)
Section 15. Regulatory Information
S. 302 (EHS)S. 304 RQ S. 313 (TRI)
EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists
147-24-0 Diphenhydramine hydrochloride No No No
CAS # Hazardous Components (Chemical Name)Other US EPA or State Lists
147-24-0 Diphenhydramine hydrochloride CAA HAP,ODC: No; CWA NPDES: No; TSCA: No; CA
PROP.65: No
Xn N
European Community Risk and Safety Phrases:
European Community Hazard Symbol codes:
Harmful if swallowed.R22
May cause sensitization by skin contact.R43
Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
R50/53
Avoid contact with skin and eyes.S24/25
Wear suitable protective clothing, gloves and eye/face protection.S36/37/39
Avoid release to the environment. Refer to special instructions / safety data sheets.S61
This SDS was prepared in accordance with Regulation (EC) No.1272/2008 and
European Directive 67/548/EEC as amended.
Regulatory Information
Statement:
Section 16. Other Information
No data available.Additional Information About
This Product:
DISCLAIMER: This information is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of merchantability
or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to
determine the suitability of the information for their particular purposes.
N.A.=Not available, N.P.=Not applicable, N.D.=Not determined, N.E.=Not established,
N.R.=Not required
Company Policy or
Disclaimer:
11/20/2013Revision Date:
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